Interestingly, 4 genes in these 2 sub-pathways were also nominally associated with prostate cancer risk: TLR1 and TLR6 in the extracellular pattern recognition sub-pathway (P = 0.002 and P = 0.04, respectively), and OAS1 and OAS2 in the intracellular antiviral molecules sub-pathway (P = 0.015 and P = 0.019, respectively). This evidence concerns the gene TLR1 and Familial prostate cancer.