MAPK3 and adenocarcinoma: In a Transgenic Adenocarcinoma Mouse Prostate (TRAMP) mouse model, resveratrol was shown to exert its anti-tumor action by increasing the expression of estrogen receptor-β and by decreasing insulin growth factor-1 (IGF-1) and extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation [9].