DISC1 and schizophrenia: Our results show that: (1) abnormal behaviors in Disc1-L100P mutant mice are present at 12 weeks but not 8 weeks of age; (2) treatment with valproic acid prevented the emergence of abnormal behaviors in Disc1-L100P mutants; (3) 23% of transcripts altered in Disc1-L100P mice are implicated in cell proliferation, including Lcn2; (4) there were more glial cells in the SVZ, RMS and OB but not in SGZ of Disc1-L100P, which was corrected by valproic acid; (5) genetic inactivation of Lcn2 corrected excess glial cells and schizophrenia-related behavior in Disc1-L100P mutants (Figure 6).