We also found that activation of the epidermal growth factor receptor (EGFR, ErbB-1, HER1)/phosphoinositide-3 kinase (PI3K)/Protein Kinase B (PKB, Akt) signaling pathway is the common mechanism of EMT and anoikis resistance in activated ACC cells. The gene discussed is AKT1; the disease is adrenal cortex carcinoma.