EGFR and adrenal cortex carcinoma: However, suppression of the PI3K/Akt signaling pathway with LY294002 (10 μM) abrogated the augmentation of Slug expression induced by EGFR activation and restored E-cadherin levels in ACC-2Ar cells, accompanied by a reversal from their spindle-shaped cell morphology toward an epithelial appearance (Figure 4C and D).