Our results revealed that the mRNA expression levels of vascular endothelial growth factor (VEGF), matrix metallopeptidase 9 (MMP9), and stromal cell-derived factor-1 alpha (SDF-1α) were up-regulated in ACC cells as they gained anoikis resistance (Figure 2E), which can account for the increased migration and invasion abilities of the variant cell lines. This evidence concerns the gene CXCL12 and adrenal cortex carcinoma.