Furthermore, regarding the association of zinc intoxication with tauopathy, high levels of zinc, up to 1000 μM, can be reached within amyloid plaques in Alzheimer’s disease [55], and there is accumulating evidence indicating that zinc enhances the development of amyloid pathology in Alzheimer’s disease [56], which in turn can induce tau pathology (e.g. [57]). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.