Apart from demonstrating these effects in vitro, our results obtained from the mice models, in which the peptides were administered after LPS, indicate the ability of GKY25 and HVF18 to protect animals from acute septic shock by reducing vascular leakage, overactivation of coagulation and inflammation as observed by a substantial decrease in a range of pro-inflammatory cytokines, e.g. IL-6 and TNF- α. This evidence concerns the gene TNF and Shock.