POU5F1 and neoplasm: The results show that CDF treatment significantly decreased the relative levels of miR-21 and miR-210, and mRNA expression of HIF-1α, VEGF, IL-6, EZH2, Nanog, and Oct4 the tumor tissues (Figure 6B), suggesting that CDF in a tumor model in vivo could inhibit the expression of miRNAs and mRNAs that are associated with CSCs and deregulated under hypoxic conditions in vitro.