NOTCH1 and neoplasm: Our earlier studies have shown that CDF could function as a potent anti-tumor agent against human pancreatic tumor in vitro and in vivo by regulating miRNAs, CSC phenotype and function, and multiple cellular signaling pathways such as NF-κB, Akt, COX-2, Notch-1, and EZH2 [17]–[19].