The results show that CDF treatment significantly decreased the relative levels of miR-21 and miR-210, and mRNA expression of HIF-1α, VEGF, IL-6, EZH2, Nanog, and Oct4 the tumor tissues (Figure 6B), suggesting that CDF in a tumor model in vivo could inhibit the expression of miRNAs and mRNAs that are associated with CSCs and deregulated under hypoxic conditions in vitro. This evidence concerns the gene EZH2 and neoplasm.