Curcumin (diferuloylmethane) is a bioactive natural compound [43], [44], and a large body of experimental studies have shown that curcumin can inhibit cell growth, cell invasion, tumor growth, and induce apoptotic cells death, which is consistent with deregulation of multiple cellular signaling pathways such as NF-κB, Notch, Akt/mTOR, Wnt, HIF-α, and Hedgehog [16], [45]–[50]. The gene discussed is AKT1; the disease is neoplasm.