Curcumin (diferuloylmethane) is a bioactive natural compound [43], [44], and a large body of experimental studies have shown that curcumin can inhibit cell growth, cell invasion, tumor growth, and induce apoptotic cells death, which is consistent with deregulation of multiple cellular signaling pathways such as NF-κB, Notch, Akt/mTOR, Wnt, HIF-α, and Hedgehog [16], [45]–[50]. This evidence concerns the gene NFKB1 and neoplasm.