TP53 and neoplasm: Despite the known weaknesses of meta-analysis, the large sample and the homogeneity of the results after adjustment add weight to our conclusions: we found that FGFR3 and TP53 mutations occurred independently when stage and grade were taken into account, and that the frequency of TP53 mutation was high in pT1G3 and pT2-4 tumours, regardless of the presence or absence of FGFR3 mutations in these tumours.