FGFR3 and neoplasm: An association between FGFR3 mutation status and category was also observed, although the trend was less clear-cut, because of the strong influence of both grade and stage on FGFR3 mutation rate: the frequency of FGFR3 mutation was very similar in pTaG1-2 tumours (70.2%) and pT1G2 tumours (64.6%), but significantly lower in pTaG3 tumours (40.5%) (χ2 test; p = 0.0001).