There was a strong association between TP53 mutations and category, as the frequency of TP53 mutations was 4.55% in pTaG1-2, 14.3% in pTaG3, 18.5% in pT1G2, 46.15% in pT1G3 and 50.25% in pT2-4 tumours, the largest difference thus being that between pT1G2 and pT1G3 tumours. Here, TP53 is linked to neoplasm.