TP53 and neoplasm: In subgroup analysis, FGFR3 and TP53 mutations were not significantly associated in pTa tumours (p = 0.20) or in pT2-4 tumours (p = 0.345), but these two types of mutation were strongly associated, even after Bonferroni correction (significance level for the three tests  =  0.017) in pT1 tumours (ORa = 0.52 [0.30, 0.88], p = 0.0009) (Table 2).