Our meta-analysis of 917 tumours (including all published data (535 tumours) plus an additional series of 382 tumours of all stages and grades) confirms and extends the findings of Hernandez et al., by showing that FGFR3 mutations and TP53 mutations are independent events not only in pT1G3 tumours (confirmed here for 260 pT1G3 tumours) but also in pTa, pT1G2 and muscle-invasive tumours (pT≥2). Here, FGFR3 is linked to neoplasm.