Defective CFTR function at the cell surface leads to drastically reduced secretions from airway epithelia, inducing persistent lung infectionsfollowed by fibrosis of lung parenchyma [17], intestinal obstruction, infertility in males, destruction of the pancreatic ducts, and high sweat chloride, symptoms common inpatients with cystic fibrosis [18]. Here, CFTR is linked to cystic fibrosis.