Hence, although Siglec-1 viral binding via sialyllactose recognition does not discriminate between infectious or noninfectious HIV-1 particles, the greater the expression of Siglec-1, the greater the amount of virions captured and transmitted by DCs, diminishing the relative contribution of DC-SIGN gp120-mediated viral capture to trans-infection. The gene discussed is ITIH4; the disease is infection.