Inhibited neuroinflammation in MS Inhibited the differentiation and expansion of Th17 cells in circulation induced by inflammatory cascade; Enhanced the expression of ZO-1; Down-regulated expression of CXC chemokines and receptor; Decreased Th17 cells to transmigrate across the blood brain barrier and the inhibition of autoreactive T cells transmigration can reduce neuroinflammation; Blocked IL17 and others, which lead to centtral system nervous tissue destruction in MS. Here, TJP1 is linked to myeloid sarcoma.