The ability of CLO-TOR to down-modulate phosphorylation of 4E-BP1 is also important, as Tamburini et al. [30] emphasized that the weak anti-leukemic activity of the rapalogs was mainly due to the sustained high level of 4E-BP1 phosphorylation in AML cells treated with these compounds. Here, EIF4EBP1 is linked to acute myeloid leukemia.