TAp73α can induce tau phosphorylation, possibly implying a role of this particular variant in Alzheimer's disease [25, 33, 36, 65, 66]; this assumption is also supported by the fact that old p73+/− heterozygous mice display signs of Alzheimer's disease, such as reduced motor and cognitive function, accumulation of tau phosphorylation, tau kinase dysregulation and CNS atrophy [26]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.