To investigate this question, we applied the Q-HTCP method to systematically query the yeast genome for modifiers of a specific phenotype resulting from Yor1-ΔF670, and provide evidence validating this yeast phenomic (genome-wide analysis of phenotypic modification due to gene interaction) model for CFTR-ΔF508, the most prevalent human allele causing cystic fibrosis [7]. This evidence concerns the gene CFTR and cystic fibrosis.