To further investigate the role of PAR-1 in the local inflammatory response, we determined levels of various cytokines (TNF-α, IL-6, IL-10, IL-12, IFN-γ) and chemokines (MCP-1, MIP-2) in lung homogenates at 6, 24 and 48 hours after infection (Table 1). Here, F2R is linked to infection.