The study reported herein was designed to analyze the status of FGFR-1 gene in a consecutive series of lobular breast carcinoma with primary and matched lymph-nodal and haematogenous metastases from lobular breast carcinomas, given no data are currently available on the FGFR-1 gene status in a metastatic setting of lobular breast carcinomas. Here, FGFR1 is linked to breast lobular carcinoma.