The data reported herein, show that: 1) FGFR-1 amplification is observed in a subset of lymph-nodal and haematogenous metastases from lobular breast carcinoma; 2) minor heterogeneity is scored in matched primary and metastatic lobular breast carcinomas; 3) in the era of tailored therapies, patients affected by the lobular subtype of breast carcinoma with FGFR-1 amplification may be considered a potential patients’ subset benefiting from FGFR-1 inhibitor. Here, FGFR1 is linked to breast lobular carcinoma.