Interestingly, Dutt et al. found gains of FGFR-1 gene in a subset of lung adenocarcinomas and squamous lung carcinomas and notably they demonstrated that a non-small cell lung carcinoma cell line harbouring focal amplification of FGFR-1 is dependent on FGFR-1 activity for cell growth, as treatment of this cell line either with FGFR1-specific shRNAs or with FGFR small molecule enzymatic inhibitors did lead to cell growth inhibition[16]. This evidence concerns the gene FGFR1 and lung adenocarcinoma.