Based on these observations, Okada et al.[18] applied α-type-1 polarizing DCs to a phase I/II clinical trial for 22 cases of HLA-A2+ high-grade glioma, where HLA-A2 peptides like EphA2, Il-13R-a2, YKL-40 and gp100 were used, and obtained 2 objective responders and 9 cases with progression-free survival for at least 12 months. This evidence concerns the gene CHI3L1 and central nervous system cancer.