Overexpression of Beclin 1 significantly enhanced proteasome inhibitors-induced cytotoxicity of ovarian cancer cells, as assessed by cleavage of PARP (Figure6A), MTT assay (Figure6B), nuclei staining with Hoechst 33258 (Figure6C), and caspase 3 activity assay (Figure6D). The gene discussed is BECN1; the disease is ovarian cancer.