Similarly, in livestock, more and more studies evidenced that CNVs play causative effects on phenotypic variations, such as CNV in intron 1 of SOX5 causing the pea-comb phenotype in chickens[19], a 4.6-kb intronic duplication in STX17 for hair greying and melanoma in horses[20], duplication of FGF3, FGF4, FGF19 and ORAOV1 resulting in hair ridge and predisposition to dermoid sinus in Ridgeback dogs[21], and CNV and missense mutations of the agouti signaling protein (ASIP) gene leading to different coat colors in goats[22]. Here, ASIP is linked to melanoma.