This effect was mostly due to tumours of the luminal B subtype because their removal from the analysis resulted in loss of the effect of TOX3 mRNA on OS and DMFS (log rank p = 0.64 and log rank p = 0.86, respectively) whereas removal of luminal A tumours had small effect on survival (OS: log rank p = 0.02 and DMFS: log rank p = 0.05; Additional file1: Figure S4). The gene discussed is TOX3; the disease is neoplasm.