In a recent genome-wide association study (GWAS), the odds ratio (OR) was 1.09 for the rs2927438 SNP in the APOE*4 locus that showed the strongest association between AD with and without psychosis, but this association did not reach statistical significance (p=.306) [5] However, the current study illustrates that these modest genetic effects might be obscured when the psychosis phenotype cannot be further subdivided (e.g., D+H or D alone). This evidence concerns the gene APOE and Alzheimer disease.