FFAR2 and obesity due to melanocortin 4 receptor deficiency: Recently, Dewulf et al. [26,27] revealed that inulin-type diets counteract high-fat diet-induced obesity via suppressing G protein-coupled receptor-43 overexpression through the modification of the gut microbiota and they resulted in a decreased level of circulating lipopolysaccharide and lower C-reactive protein levels to attenuate inflammation.