Moreover, a prominent role for Ly49 receptors (Ljunggren and Karre, 1985; Karre et al., 1986; Glas et al., 1992, 2000; Koh et al., 2001), NK group 2 member D (NKG2D) activating receptors (Diefenbach et al., 2001), DNAX accessory molecule-1 (DNAM-1; Lakshmikanth et al., 2009), and components of the NK cell secretory and cytotoxic machinery (Street et al., 2001; Takeda et al., 2011), TRAIL (Taieb et al., 2006) was reported in the control of tumor growth and metastases in mice. Here, CD226 is linked to neoplasm.