Recently, the B16F10 transplantable mouse melanoma model transfected with chemerin, a chemoattractant for NK cells, macrophages, and DC subsets (Wittamer et al., 2003; Zabel et al., 2005; Parolini et al., 2007), led to a significant recruitment of NK cells in the tumor responsible for tumor regression (Pachynski et al., 2012). This evidence concerns the gene RARRES2 and melanoma.