As meningeal and parenchymal blood vessels differ from one another in several aspects [64], including the absence of a glial ensheathment in leptomeningeal vessels [70] and the constitutive expression of P-selectin in meningeal but not parenchymal microvessels [6], studying meningeal vessels in stroke is not a substitute for cortical microvessels. The gene discussed is SELP; the disease is Stroke.