A number of the properties of the KI mice, however, were surprisingly different from those of PSD-95 KO mice, e.g., reduced levels of PSD-93 and AMPAR subunits in PSDs during development, normal magnitude of LTD induction, noticeably small body weight, marked hypokinetics in an unfamiliar environment, and markedly abnormal anxiety-related behavior. The gene discussed is DLG4; the disease is Anxiety.