In studies with concurrent use of first trimester uterine artery pulsatility index (UAPI), biochemical (PlGF or pregnancy associated plasma protein A) and arterial blood pressure (mean arterial or central augmentation index), there were good detection rate and discriminatory power between variants of hypertensive disorders (gestational hypertension, early and late pre-eclampsia)[22-25]. Here, PGF is linked to hypertensive disorder.