The compound, n-butylidenephthalide, isolated from the chloroform extract of Angelica siensis was found to upregulate the expression of p21 and p27 and increase apoptosis-associated proteins in DBTRG-05MG and RG2 cells and suppress the growth of subcutaneous rat and human brain tumors [26]. Here, CDKN1B is linked to brain neoplasm.