CD72 and systemic lupus erythematosus: This finding indicates that CD72*2 confers resistance to SLE in individuals carrying FCGR2B-Ile232Thr. Two polymorphisms in intron 8 regulate generation of an alternative splicing isoform (CD72Δex8) that skips exon 8 independently; probably act in combination as cis-acting intronic splicing enhancer (ISE) or silencer (ISS) [7].