We previously demonstrated that CD72*2 specifically abrogates the susceptibility to SLE conferred by the allele of FcγRIIb carrying the substitution of 232Ile by 232Thr (FCGR2B-Ile232Thr) [7], which is suggested to reduce the inhibitory function of FcγRIIb [23]. This evidence concerns the gene CD72 and systemic lupus erythematosus.