The frequency of the A allele (rs2241712) of the TGF-β1 gene was significantly higher in COPD patients (52%) than in healthy controls (45%) (OR=1.24, 95% CI 0.96–1.59, p=0.0460, p(Bonferroni)=3.7848). The gene discussed is TGFB1; the disease is chronic obstructive pulmonary disease.