Circulating oxidized LDL-containing immune complexes (oxLDL-IC) are increased in diabetes stimulate synthesis of IgGs in addition to other proinflammatory cytokines such as IL-1β, IL-6, IL-18, and TNF-α in Mono Mac 6 cells and primary human macrophages (Saad et al., 2006; Abdelsamie et al., 2011). This evidence concerns the gene TNF and diabetes mellitus.