On the other hand, several studies have reported that the AT2 receptor activates PP2A phosphatase (Huang et al., 1995, 1996a; Kilian et al., 2008), which is markedly deficient in AD (Gong et al., 1993, 2000; Wang et al., 2007) and implicated in glycogen synthase kinase-3 (GSK-3) inactivation via a sustained increase in p42/p44mapk. This evidence concerns the gene AGTR2 and Alzheimer disease.