MAPK1 and cancer: Binds B-Raf, MEK, and ERK and facilities ERK activation at specific levels of EGF or insulin-like growth factor, which shows that optimal ERK/MAPK activation requires a balanced stoichiometry of the IQGAP1 to signaling proteins (Roy et al., 2004). IQAGP1 is over-expressed in some cancers such as breast and ovarian, therefore its scaffolding functions for the ERK pathway may contribute significantly to tumorigenesis (Jadeski et al., 2008).