Binds B-Raf, MEK, and ERK and facilities ERK activation at specific levels of EGF or insulin-like growth factor, which shows that optimal ERK/MAPK activation requires a balanced stoichiometry of the IQGAP1 to signaling proteins (Roy et al., 2004). IQAGP1 is over-expressed in some cancers such as breast and ovarian, therefore its scaffolding functions for the ERK pathway may contribute significantly to tumorigenesis (Jadeski et al., 2008). The gene discussed is IQGAP1; the disease is cancer.