In general terms, orexigenic signals (fasting, hypoglycemia, ghrelin, etc.)in the hypothalamus activate AMPK, while anorexigenic signals (feeding, hyperglycemia, insulin, leptin, etc.)exert the opposite effect (Minokoshi et al., 2004; Blanco Martinez de Morentin et al., 2011). This evidence concerns the gene PRKAA2 and Hypoglycemia.