The aim of this study was to determine, by histochemsitry, the over-expression of antigen TF and galectin-3 in fibroadenoma and healthy breast tissues, using specific lectins for antigen TF and anti-galectin-3 antibody, to understand better the potential role of O-glycosylation in fibroadenomas’ progression. The gene discussed is LGALS3; the disease is Fibroadenoma.