TF-thrombin axis enhances the inflammatory response in several clinical models such as arthritis (Busso et al., 2003) antiphospholipid syndrome (APS) (Ritis et al., 2006; Redecha et al., 2007, 2008), ischemia/reperfusion injury (Loubele et al., 2009), and sepsis (Osterud and Bjorklid, 2001; Aras et al., 2004; Wang et al., 2009). The gene discussed is TF; the disease is autoimmune polyendocrinopathy.