TFPI and Sepsis: Further studies in animal models of sepsis demonstrated that extrinsic coagulation cascade inhibition with a varying range of anticoagulants [natural anticoagulants, Tissue Factor Pathway Inhibitor (TFPI), Protein C, and Antithrombin III] attenuated the persisting inflammation (Taylor et al., 1987, 1998a,b; Ramachandran and Hollenberg, 2008).