Of 35 inflammation-related genes examined, these unstable RA patients exhibited increased expression of 25 genes (B7, C1QA, CD14, CD19, CD4, CD8A, CXCL1, HMOX1, HSPA1A, ICAM1, IL10, IL15, IL18, IL18BP, IL1RN, IL1B, MMP9, PTGS2, PTPRC, SERPINE1, TGFB1, TIMP1, TNF, TNFSF13B, TNFSF6, and VEGF) and decreased expression of 1 gene (CD19) compared to healthy controls (P < 0.05) (Table 3, Figure 1A). Here, ICAM1 is linked to rheumatoid arthritis.