ESR1 and breast carcinoma: Several of the genes involved are also in signalling pathways relevant to breast cancer: ERBB2, NRIP1 and BCAS3 are involved in estrogen receptor function and APPBP2 with androgen receptor; while TAOK1 and SKAP1 are involved in MAPK signalling and DEPDC6/DEPTOR regulates mTOR signalling.