NFKB1 and neoplasm: The dual role of NF-κB activation in the modulation of tumor cell response to chemotherapeutic agents appears to result from the ability of this transcription factor to either activate or repress transcription of genes involved in cell proliferation and survival, depending on which specific post-translational modifications and interaction with transcription co-activator or repressors occur in the malignant cells [1,3,23,51].