To analyze the functional relevance of this pathway, two models of experimental liver fibrosis were applied to wildtype (WT) and CX3CR1-deficient mice, namely repetitive carbon tetrachloride (CCl4) injections as well as surgical ligation of the biliary duct (BDL, bile duct ligation) [48]. The gene discussed is CX3CR1; the disease is Hepatic fibrosis.