Moreover, the effects of statins seem to influence pathways leading to Ang II-mediated atherosclerosis and we previously demonstrated, in circulating neutrophils of high-cardiovascular risk patients, interferences of treatment on both AT1R expression and the cell membrane translocation Rac 1, a guanosine triphosphate–binding protein playing a key role in Ang II–operated signaling pathways[12]. This evidence concerns the gene AGT and atherosclerosis.