The use of interferon-gamma (IFN-γ) to treat invasive fungal infections is derived from animal models that showed resistance to disease correlated with an intact Th1 response [6] and protection was associated with high levels of tumor necrosis factor alpha (TNF-α), interleukin-2 (IL-2), interleukin-12 (IL-12), and IFN-γ [7]. This evidence concerns the gene TNF and fungal infectious disease.