Cilloni et al. [161] demonstrated that a selective inhibitor of the IκB kinase (IKK) was capable of reducing NFκB binding activity and proliferation, followed by induction of apoptosis in CML cell lines sensitive and resistant to imatinib, as well as in bone marrow cells from sensitive and resistant CML patients. This evidence concerns the gene NFKB1 and chronic myelogenous leukemia, BCR-ABL1 positive.