Hypermethylation of the promoters of various tumor suppressors such as miR-124-1 (a target of CDK6) [66], miR-203 (a target of cyclic-responsive element-binding protein which increases proliferation) [67], and miR-29b (a target of Mcl-1 which antagonizes IL-6) increase the tumorigenicity of myeloma cells [68]. The gene discussed is IL6; the disease is plasma cell myeloma.