BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Unfortunately, resistance to kinase inhibitors frequently develops, and G. N. de Moraes et al. in a review entitled “The interface between BCR-ABL-dependent and -independent resistance signaling pathways in chronic myeloid leukemia” analyze the known causes for this resistance and offer several feasible molecular targets, which may overcome the development of resistance to kinase inhibitors in CML.