EIF2AK2 and acute myeloid leukemia: The report of these studies, entitled “PKCδ regulates translation initiation through PKR and eIF2α in response to retinoic acid in acute myeloid leukemia cells” also indicates that ATRA/ATO inhibit the PI3K/AKT/mTOR pathway, leading to an upregulation of the PKC delta/PKR axis.