CCR4 and Increased total eosinophil count: Additional factors associated with a poor prognosis include thrombocytopenia, eosinophilia, bone marrow involvement, a high interleukin (IL)-5 serum-level, C-C chemokine receptor 4 (CCR4) expression, lung resistance-related protein (LRP), p53 mutation, and p16 deletion by multivariate analysis [26, 27, 33–37].