ACE and Stroke: However, considering the results of a 5.5-year follow-up study by the Angio-Scandinavian Cardiac Outcomes Trial-BP-Lowering Arm (ASCOT-BPLA) that calcium channel blockers and ACE inhibitor combination therapy significantly lowers BP by 2.7/1.9 mm Hg and thus decreases the risk of cardiovascular death and stroke, even a small decrease in BP can have a clinical significance if long-term maintenance can be achieved [2].