Actions shared by exendin-4 and GLP-1 in non-human studies include reduction of hyperglycemia, glucose-dependent enhancement of insulin secretion, glucose-dependent suppression of inappropriately high glucagon secretion, slowing of gastric emptying, and reduction of food intake, often with body weight reduction or blunting of weight gain [39,44,46-49]. This evidence concerns the gene INS and Hyperglycemia.