More recently, a meta-analysis yielded a statistically significant association between GPA and the rs3087243 gene polymorphism in Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4)[11], also known to enhance the development of ACPA-positive RA as compared with ACPA-negative RA[12]. The gene discussed is PRTN3; the disease is rheumatoid arthritis.