Other groups have reported that low-dose whole-body RT increased expression of TLR4/MD2 and CD14 expression on murine peritoneal macrophages, leading to increased secretion of anti-tumor cytokines including IL-12 and IL-18, thus indicating that RT increases anti-tumor potential of macrophages (Shan et al., 2007). The gene discussed is TLR4; the disease is neoplasm.