DDIT3 and neoplasm: While after the 4th passage (four courses of CHOP for the tumor and only one for the liver) the volume density of necrotic changes in the liver increased 1.3-fold and the volume density of degenerative change decreased 1.4-fold in comparison with the 1st passage of the tumor, which attests to the possible transformation of degeneration into necrosis (Table 1).